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Rat Hmgcr ORF Clone(NM_013134.2)

For research use only. Not intended for any clinical use.

Cat. No. :   CDCR377980

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Gene Information

Cat. No. CDCR377980
Product Type ORF Clone
Gene Abbr Hmgcr
Species Rat
Tag C-terminal Myc-DDK
ORF Size 2664 bp
Vector pCMV6-Entry
Target Gene HMGCR
Background HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
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