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Rat Gclc cDNA Clone(NM_012815.2)

For research use only. Not intended for any clinical use.

Cat. No. :   CDFR010672

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Gene Information

Cat. No. CDFR010672
Description NativeORF clone of Rattus norvegicus glutamate-cysteine ligase, catalytic subunit (Gclc) as transfection-ready DNA NM_012815.2
Product Type cDAN Clone
Gene Abbr Gclc
Species Rat
Vector pCMV6Entry
Target Gene GCLC
Background Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate-limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. This locus encodes the catalytic subunit, while the regulatory subunit is derived from a different gene located on chromosome 1p22-p21. Mutations at this locus have been associated with hemolytic anemia due to deficiency of gamma-glutamylcysteine synthetase and susceptibility to myocardial infarction.[provided by RefSeq, Oct 2010]
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