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Rat Fadd ORF Clone(NM_152937.2)

For research use only. Not intended for any clinical use.

Cat. No. :   CDCR381658

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Gene Information

Cat. No. CDCR381658
Product Type ORF Clone
Gene Abbr Fadd
Species Rat
Tag C-terminal Myc-DDK
ORF Size 627 bp
Vector pCMV6-Entry
Target Gene FADD
Background The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development. [provided by RefSeq, Jul 2008]
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