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Rat Dnmt1 cDNA Clone(NM_053354.3)

For research use only. Not intended for any clinical use.

Cat. No. :   CDFR013109

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Gene Information

Cat. No. CDFR013109
Description NativeORF clone of Rattus norvegicus DNA (cytosine-5-)-methyltransferase 1 (Dnmt1) as transfection-ready DNA NM_053354.3
Product Type cDAN Clone
Gene Abbr Dnmt1
Species Rat
Vector pCMV6Entry
Target Gene DNMT1
Background This gene encodes an enzyme that transfers methyl groups to cytosine nucleotides of genomic DNA. This protein is the major enzyme responsible for maintaining methylation patterns following DNA replication and shows a preference for hemi-methylated DNA. Methylation of DNA is an important component of mammalian epigenetic gene regulation. Aberrant methylation patterns are found in human tumors and associated with developmental abnormalities. Variation in this gene has been associated with cerebellar ataxia, deafness, and narcolepsy, and neuropathy, hereditary sensory, type IE. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
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