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Rat Cd3e ORF Clone(NM_001108140.1)

For research use only. Not intended for any clinical use.

Cat. No. :   CDCR374698

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Gene Information

Cat. No. CDCR374698
Product Type ORF Clone
Gene Abbr Cd3e
Species Rat
Tag C-terminal Myc-DDK
ORF Size 567 bp
Vector pCMV6-Entry
Target Gene CD3E
Background The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women. [provided by RefSeq, Jul 2008]
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