Rat Cbfb cDNA Clone(NM_001013191.1)

Name: Rat Cbfb cDNA Clone(NM_001013191.1)
SKU: CDFR002721
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDFR002721

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Product Information

Gene Information

Cat. No.	CDFR002721
Description	NativeORF clone of Rattus norvegicus core-binding factor, beta subunit (Cbfb) as transfection-ready DNA NM_001013191.1
Product Type	cDAN Clone
Gene Abbr	Cbfb
Species	Rat
Size	10 ug
Vector	pCMV6Entry

Target Gene

CBFB

Background

The protein encoded by this gene is the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2/CBF transcription factor family which master-regulates a host of genes specific to hematopoiesis (e.g., RUNX1) and osteogenesis (e.g., RUNX2). The beta subunit is a non-DNA binding regulatory subunit; it allosterically enhances DNA binding by alpha subunit as the complex binds to the core site of various enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers and GM-CSF promoters. Alternative splicing generates two mRNA variants, each encoding a distinct carboxyl terminus. In some cases, a pericentric inversion of chromosome 16 [inv(16)(p13q22)] produces a chimeric transcript consisting of the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain 11. This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

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