Rat Cbfb ORF Clone(NM_001013191.1)

Name: Rat Cbfb ORF Clone(NM_001013191.1)
SKU: CDCR369952
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDCR369952

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Product Information

Gene Information

Cat. No.	CDCR369952
Product Type	ORF Clone
Gene Abbr	Cbfb
Species	Rat
Tag	C-terminal Myc-DDK
ORF Size	549 bp
Vector	pCMV6-Entry

Target Gene

CBFB

Background

The protein encoded by this gene is the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2/CBF transcription factor family which master-regulates a host of genes specific to hematopoiesis (e.g., RUNX1) and osteogenesis (e.g., RUNX2). The beta subunit is a non-DNA binding regulatory subunit; it allosterically enhances DNA binding by alpha subunit as the complex binds to the core site of various enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers and GM-CSF promoters. Alternative splicing generates two mRNA variants, each encoding a distinct carboxyl terminus. In some cases, a pericentric inversion of chromosome 16 [inv(16)(p13q22)] produces a chimeric transcript consisting of the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain 11. This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

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