Rat Cav1 cDNA Clone(NM_133651.2)

Name: Rat Cav1 cDNA Clone(NM_133651.2)
SKU: CDFR014133
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDFR014133

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Product Information

Gene Information

Cat. No.	CDFR014133
Description	NativeORF clone of Rattus norvegicus caveolin 1, caveolae protein (Cav1), transcript variant 2 as transfection-ready DNA NM_133651.2
Product Type	cDAN Clone
Gene Abbr	Cav1
Species	Rat
Vector	pCMV6Entry

Target Gene

CAV1

Background

The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 mitogen-activated kinase cascade. Caveolin 1 and caveolin 2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. Mutations in this gene have been associated with Berardinelli-Seip congenital lipodystrophy. Alternatively spliced transcripts encode alpha and beta isoforms of caveolin 1.[provided by RefSeq, Mar 2010]

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