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Cav1 Knockout Mouse Bone Marrow Neutrophils

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Cat.No.
CSC-RK0183
Background
Caveolin-1 is a protein that in humans is encoded by the CAV1 gene. The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 MAP kinase cascade. CAV1 and CAV2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. By using alternative initiation codons in the same reading frame, two isoforms (alpha and beta) are encoded by a single transcript from this gene.
Growth Properties
Suspension
Host Cell
Bone marrow neutrophils
Ship
Dry ice
Gene Information
Official Symbol
Cav1
Synonyms
CAV1; caveolin 1, caveolae protein; caveolin-1; caveolin, caveolae protein 1; caveolin, caveolae protein, 22 kDa; Cav; Cav-1;
Gene ID
Pathway
Androgen Receptor Signaling Pathway, organism-specific biosystem; Bacterial invasion of epithelial cells, organism-specific biosystem; Bacterial invasion of epithelial cells, conserved biosystem; Basigin interactions, organism-specific biosystem; Cell surface interactions at the vascular wall, organism-specific biosystem; EGFR1 Signaling Pathway, organism-specific biosystem; Endocytosis, organism-specific biosystem;
Function
SNARE binding; kinase binding; nitric-oxide synthase binding; patched binding; peptidase activator activity; protein binding; receptor binding; structural molecule activity; syntaxin binding;

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