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Nos3/Cav1 Knockout Mouse Bone Marrow Neutrophils

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Caveolin-1 is a protein that in humans is encoded by the CAV1 gene. The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression.
Nitric oxide synthases (EC (NOSs) are a family of enzymes that catalyze the production of nitric oxide (NO) from L-arginine. NO is an important cellular signaling molecule, having a vital role in many biological processes. It is the intercellular signal that controls vascular tone (hence blood pressure), insulin secretion, airway tone, and peristalsis, and is involved in angiogenesis (growth of new blood vessels) and in the development of nervous system. It is believed to function as a retrograde neurotransmitter and hence is likely to be important in learning. Nitric oxide signalling is mediated in mammals by the calcium/calmodulin controlled isoenzymes eNOS (endothelial NOS) and nNOS (neuronal NOS); the inducible isoform iNOS is involved in immune response, binds calmodulin at all physiologically relevant concentrations, and produces large amounts of NO as a defense mechanism. It is the proximate cause of septic shock and may play a role in many diseases with an autoimmune etiology.
Growth Properties
Host Cell
Bone marrow neutrophils
Dry ice
Gene Information
Official Symbol
NOS3; nitric oxide synthase 3, endothelial cell; nitric oxide synthase, endothelial; cNOS; EC-NOS; NOSIII; NOS type III; endothelial NOS; constitutive NOS; endothelial nitric oxide synthase; eNOS; Nos-3; ecNOS; 2310065A03Rik;
Gene ID
ACE Inhibitor Pathway, organism-specific biosystem; Arginine and proline metabolism, organism-specific biosystem; Arginine and proline metabolism, conserved biosystem; Calcium signaling pathway, organism-specific biosystem; Calcium signaling pathway, conserved biosystem; Hemostasis, organism-specific biosystem; Metabolic pathways, organism-specific biosystem;
FMN binding; Hsp90 protein binding; NADP binding; actin monomer binding; arginine binding; calmodulin binding; flavin adenine dinucleotide binding; heme binding; iron ion binding; metal ion binding; nitric-oxide synthase activity; nitric-oxide synthase activity; oxidoreductase activity; tetrahydrobiopterin binding;

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