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Rat Casp3 ORF Clone(NM_012922.2)

For research use only. Not intended for any clinical use.

Cat. No. :   CDCR377777

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Product Information

Gene Information

Cat. No. CDCR377777
Product Type ORF Clone
Gene Abbr Casp3
Species Rat
Tag C-terminal Myc-DDK
ORF Size 834 bp
Vector pCMV6-Entry
Target Gene CASP3
Background The protein encoded by this gene is a cysteine-aspartic acid protease that plays a central role in the execution-phase of cell apoptosis. The encoded protein cleaves and inactivates poly(ADP-ribose) polymerase while it cleaves and activates sterol regulatory element binding proteins as well as caspases 6, 7, and 9. This protein itself is processed by caspases 8, 9, and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. [provided by RefSeq, Aug 2017]
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