Transfected Stable Cell Lines
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Cat. No. : CDCL183122
| Cat. No. | CDCL183122 |
| Description | ORF Clone of Rattus norvegicus chemokine (C-C motif) ligand 5 DNA. |
| Product Type | ORF clone |
| Gene Abbr | CCL5 |
| Species | Rat |
| ORF Size | 279bp |
| Vector | pMD18-T |
| Warning | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Storage | store at -20°C |
| Target Gene | CCL5 |
| Background | This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, functions as a chemoattractant for blood monocytes, memory T helper cells and eosinophils. It causes the release of histamine from basophils and activates eosinophils. This cytokine is one of the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the natural ligands for the chemokine receptor chemokine (C-C motif) receptor 5 (CCR5), and it suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Jul 2013] |
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