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Rat CCL5 ORF clone(NM_031116.3)

For research use only. Not intended for any clinical use.

Cat. No. :   CDCL183122

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Product Information

Gene Information

Cat. No. CDCL183122
Description ORF Clone of Rattus norvegicus chemokine (C-C motif) ligand 5 DNA.
Product Type ORF clone
Gene Abbr CCL5
Species Rat
ORF Size 279bp
Vector pMD18-T
Warning This product is for research use only. Not for use in diagnostic or therapeutic procedures.
Storage store at -20°C
Target Gene CCL5
Background This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, functions as a chemoattractant for blood monocytes, memory T helper cells and eosinophils. It causes the release of histamine from basophils and activates eosinophils. This cytokine is one of the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the natural ligands for the chemokine receptor chemokine (C-C motif) receptor 5 (CCR5), and it suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Jul 2013]
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