Rat Bax ORF Clone(NM_017059.2)

Name: Rat Bax ORF Clone(NM_017059.2)
SKU: CDCR378159
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDCR378159

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Product Information

Gene Information

Cat. No.	CDCR378159
Product Type	ORF Clone
Gene Abbr	Bax
Species	Rat
Tag	C-terminal Myc-DDK
ORF Size	579 bp
Vector	pCMV6-Entry

Target Gene

BAX

Background

The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. The association and the ratio of BAX to BCL2 also determines survival or death of a cell following an apoptotic stimulus. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene. [provided by RefSeq, Dec 2019]

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