Human BAX Knockdown Cell Line-HeLa

Name: Human BAX Knockdown Cell Line-HeLa
SKU: CSC-RK0257
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CSC-RK0257

Host Cell : HeLa Validation : Real-Time RCR

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Cell Line Information

Safety and Packaging

Gene Information

Cat. No.	CSC-RK0257
Target Gene	BAX
Abbr	HeLa-HuBAX Knockdown
Alias	BAX, BCL2L4, bcl2-L-4
Host Cell	HeLa
Host Cell Species	Homo sapiens (Human)
Applications	(1) Studying gene functions (2) Studying gene interactions and signaling pathways (3) Target validation and drug discovery (4) Designing diseases models
Morphology	Epithelial
Size	>1 × 10⁶ cells / vial
Stability	Validated for at least 10 passages
Validation	Real-Time RCR
Shipping	Dry ice

Mycoplasma	Negative
Format	One frozen vial containing millions of cells
Storage	Liquid nitrogen
Safety Considerations	The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach.
Ship	Dry ice

Gene Name	BAX BCL2-associated X protein [ Homo sapiens ]
Gene Symbol	BAX
Synonyms	BCL2L4
Gene Description	BCL2-associated X protein
Gene ID	581
Uni Prot ID	Q07812
m RNA Refseq	NM_138761.3
Protein Refseq	NP_620116.1
Chromosome Location	19q13.3-q13.4
Function	BH3 domain binding; BH3 domain binding; channel activity; identical protein binding; lipid binding; protein binding; protein heterodimerization activity; protein homodimerization activity; protein homodimerization activity;
Pathway	Activation, translocation and oligomerization of BAX, organism-specific biosystem; Amyotrophic lateral sclerosis (ALS), organism-specific biosystem; Amyotrophic lateral sclerosis (ALS), conserved biosystem; Apoptosis, organism-specific biosystem; Apoptosis, organism-specific biosystem; Apoptosis, conserved biosystem; Apoptosis, organism-specific biosystem;
MIM	600040

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Customer Reviews

The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene.

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