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Rat Apex1 cDNA Clone(NM_024148.1)

For research use only. Not intended for any clinical use.

Cat. No. :   CDFR012278

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Gene Information

Cat. No. CDFR012278
Description NativeORF clone of Rattus norvegicus APEX nuclease (multifunctional DNA repair enzyme) 1 (Apex1) as transfection-ready DNA NM_024148.1
Product Type cDAN Clone
Gene Abbr Apex1
Species Rat
Vector pCMV6Entry
Target Gene APEX1
Background The APEX gene encodes the major AP endonuclease in human cells. It encodes the APEX endonuclease, a DNA repair enzyme with apurinic/apyrimidinic (AP) activity. Such AP activity sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. The AP sites are the most frequent pre-mutagenic lesions that can prevent normal DNA replication. Splice variants have been found for this gene; all encode the same protein. Disruptions in the biological functions related to APEX are associated with many various malignancies and neurodegenerative diseases.[provided by RefSeq, Dec 2019]
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