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Human APEX1 Knockdown Cell Line-LN428 Glioma

Cat.No.
CSC-RK0226
Abbr
LN428 Glioma-HuAPEX1 Knockdown
Alias
APEX1,APE,APE 1,APEN,APX,HAP1,REF 1,REF1,APE1,APEX,
Growth Properties
Adherent
Host Cell
LN428 glioma
Morphology
Epithelial
Shipping
Dry ice
Species
Human
Background
Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5" to the AP site. This gene encodes the major AP endonuclease in human cells. Splice variants have been found for this gene; all encode the same protein.

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