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Rat A2m cDNA Clone(NM_012488.2)

For research use only. Not intended for any clinical use.

Cat. No. :   CDFR010166

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Gene Information

Cat. No. CDFR010166
Description NativeORF clone of Rattus norvegicus alpha-2-macroglobulin (A2m) as transfection-ready DNA NM_012488.2
Product Type cDAN Clone
Gene Abbr A2m
Species Rat
Vector pCMV6Entry
Target Gene A2M
Background The protein encoded by this gene is a protease inhibitor and cytokine transporter. It uses a bait-and-trap mechanism to inhibit a broad spectrum of proteases, including trypsin, thrombin and collagenase. It can also inhibit inflammatory cytokines, and it thus disrupts inflammatory cascades. Mutations in this gene are a cause of alpha-2-macroglobulin deficiency. This gene is implicated in Alzheimer's disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. A related pseudogene, which is also located on the p arm of chromosome 12, has been identified. [provided by RefSeq, Nov 2016]
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