Pages
Products

Rat A2m ORF Clone(NM_012488.2)

For research use only. Not intended for any clinical use.

Cat. No. :   CDCR377397

Inquire for Price

Product Information

Gene Information

Cat. No. CDCR377397
Product Type ORF Clone
Gene Abbr A2m
Species Rat
Tag C-terminal Myc-DDK
ORF Size 4419 bp
Vector pCMV6-Entry
Target Gene A2M
Background The protein encoded by this gene is a protease inhibitor and cytokine transporter. It uses a bait-and-trap mechanism to inhibit a broad spectrum of proteases, including trypsin, thrombin and collagenase. It can also inhibit inflammatory cytokines, and it thus disrupts inflammatory cascades. Mutations in this gene are a cause of alpha-2-macroglobulin deficiency. This gene is implicated in Alzheimer's disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. A related pseudogene, which is also located on the p arm of chromosome 12, has been identified. [provided by RefSeq, Nov 2016]
Quick Inquiry

Q & A

Customer Reviews

Ask a Question

If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.

Write a Review

Write a review of your use of Biogene products and services in your research. Your review can help your fellow researchers make informed purchasing decisions.

Needs improvement

Satisfaction

General satisfaction

Very satisfaction