Mouse Tank ORF clone (NM_001164071.1)

Name: Mouse Tank ORF clone (NM_001164071.1)
SKU: CDCH088716
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDCH088716

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Product Information

Gene Information

Cat. No.	CDCH088716
Description	Mus musculus TRAF family member-associated Nf-kappa B activator (Tank), transcript variant 1, mRNA.
Product Type	ORF clone
Gene Abbr	Tank
Species	Mouse
ORF Size	1245bp
Format	purified plasmid
Vector	pDONR
Warning	Please note that the protein for this clone has been annotated or predicted in the UNIPROT database to have a signal peptide. Placing a tag at the N-terminus of this protein may result in loss of the signal peptide function.

Target Gene

TANK

Background

The TRAF (tumor necrosis factor receptor-associated factor) family of proteins associate with and transduce signals from members of the tumor necrosis factor receptor superfamily. The protein encoded by this gene is found in the cytoplasm and can bind to TRAF1, TRAF2, or TRAF3, thereby inhibiting TRAF function by sequestering the TRAFs in a latent state in the cytoplasm. For example, the protein encoded by this gene can block TRAF2 binding to LMP1, the Epstein-Barr virus transforming protein, and inhibit LMP1-mediated NF-kappa-B activation. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]

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