Transfected Stable Cell Lines
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Cat. No. : CDCR253184
| Cat. No. | CDCR253184 |
| Product Type | ORF Clone |
| Gene Abbr | Grm1 |
| Species | Mouse |
| Tag | C-terminal Myc-DDK |
| ORF Size | 3600 bp |
| Size | 10 ug |
| Vector | pCMV6-Entry |
| Target Gene | Grm1 |
| Background | Enables G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration and G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential. Involved in several processes, including positive regulation of MAPK cascade; regulation of sensory perception of pain; and synaptic signaling via neuropeptide. Acts upstream of or within L-glutamate import across plasma membrane and cellular response to electrical stimulus. Located in dendrite; nucleus; and postsynaptic density. Is active in Schaffer collateral - CA1 synapse and glutamatergic synapse. Is expressed in several structures, including appendicular skeleton; eye; nervous system; testis; and tongue. Used to study autosomal recessive spinocerebellar ataxia 13; skin melanoma; and uveal melanoma. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 13 and spinocerebellar ataxia 44. Orthologous to human GRM1 (glutamate metabotropic receptor 1). [provided by Alliance of Genome Resources, Feb 2025] |
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