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Mouse Grm1 ORF Clone(NM_016976.3)

For research use only. Not intended for any clinical use.

Cat. No. :   CDCR253184

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Gene Information

Cat. No. CDCR253184
Product Type ORF Clone
Gene Abbr Grm1
Species Mouse
Tag C-terminal Myc-DDK
ORF Size 3600 bp
Size 10 ug
Vector pCMV6-Entry
Target Gene Grm1
Background Enables G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration and G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential. Involved in several processes, including positive regulation of MAPK cascade; regulation of sensory perception of pain; and synaptic signaling via neuropeptide. Acts upstream of or within L-glutamate import across plasma membrane and cellular response to electrical stimulus. Located in dendrite; nucleus; and postsynaptic density. Is active in Schaffer collateral - CA1 synapse and glutamatergic synapse. Is expressed in several structures, including appendicular skeleton; eye; nervous system; testis; and tongue. Used to study autosomal recessive spinocerebellar ataxia 13; skin melanoma; and uveal melanoma. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 13 and spinocerebellar ataxia 44. Orthologous to human GRM1 (glutamate metabotropic receptor 1). [provided by Alliance of Genome Resources, Feb 2025]
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