Mouse GRM1 ORF clone (NM_001114329.1)

Name: Mouse GRM1 ORF clone (NM_001114329.1)
SKU: CDCL114837
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDCL114837

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Product Information

Gene Information

Cat. No.	CDCL114837
Description	Homo sapiens glutamate receptor, metabotropic 1 (GRM1), transcript variant 2, mRNA.
Product Type	ORF clone
Gene Abbr	GRM1
Species	Human
ORF Size	2721bp
Format	purified plasmid
Vector	pDONR
Warning	Please note that the protein for this clone has been annotated or predicted in the UNIPROT database to have a signal peptide. Placing a tag at the N-terminus of this protein may result in loss of the signal peptide function.

Target Gene

Grm1

Background

Enables G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration and G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential. Involved in several processes, including positive regulation of MAPK cascade; regulation of sensory perception of pain; and synaptic signaling via neuropeptide. Acts upstream of or within L-glutamate import across plasma membrane and cellular response to electrical stimulus. Located in dendrite; nucleus; and postsynaptic density. Is active in Schaffer collateral - CA1 synapse and glutamatergic synapse. Is expressed in several structures, including appendicular skeleton; eye; nervous system; testis; and tongue. Used to study autosomal recessive spinocerebellar ataxia 13; skin melanoma; and uveal melanoma. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 13 and spinocerebellar ataxia 44. Orthologous to human GRM1 (glutamate metabotropic receptor 1). [provided by Alliance of Genome Resources, Feb 2025]

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