Mouse Fbxw7 ORF Clone(NM_080428.3)

Name: Mouse Fbxw7 ORF Clone(NM_080428.3)
SKU: CDCR264792
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDCR264792

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Product Information

Gene Information

Cat. No.	CDCR264792
Product Type	ORF Clone
Gene Abbr	Fbxw7
Species	Mouse
Tag	C-terminal TurboGFP
ORF Size	1890 bp
Vector	pCMV6-AC-GFP

Target Gene

FBXW7

Background

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene was previously referred to as FBX30, and belongs to the Fbws class; in addition to an F-box, this protein contains 7 tandem WD40 repeats. This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Mutations in this gene are detected in ovarian and breast cancer cell lines, implicating the gene's potential role in the pathogenesis of human cancers. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012]

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