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Mouse Axin1 cDNA Clone(NM_009733.2)

For research use only. Not intended for any clinical use.

Cat. No. :   CDFL001682

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Product Information

Gene Information

Cat. No. CDFL001682
Product Type cDNA clone
Gene Abbr Axin1
Species Mouse
Size 10 ug
Vector pCMV6Entry
Target Gene AXIN1
Background This gene encodes a cytoplasmic protein which contains a regulation of G-protein signaling (RGS) domain and a dishevelled and axin (DIX) domain. The encoded protein interacts with adenomatosis polyposis coli, catenin beta-1, glycogen synthase kinase 3 beta, protein phosphate 2, and itself. This protein functions as a negative regulator of the wingless-type MMTV integration site family, member 1 (WNT) signaling pathway and can induce apoptosis. The crystal structure of a portion of this protein, alone and in a complex with other proteins, has been resolved. Mutations in this gene have been associated with hepatocellular carcinoma, hepatoblastomas, ovarian endometriod adenocarcinomas, and medullablastomas. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
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