Mouse Axin1 ORF clone (NM_009733.2)

Name: Mouse Axin1 ORF clone (NM_009733.2)
SKU: CDCR032580
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDCR032580

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Product Information

Gene Information

Cat. No.	CDCR032580
Description	Mus musculus axin 1 (Axin1), transcript variant 2, mRNA.
Product Type	ORF clone
Gene Abbr	Axin1
Species	Mouse
ORF Size	2607
Format	purified plasmid
Vector	pDONR

Target Gene

AXIN1

Background

This gene encodes a cytoplasmic protein which contains a regulation of G-protein signaling (RGS) domain and a dishevelled and axin (DIX) domain. The encoded protein interacts with adenomatosis polyposis coli, catenin beta-1, glycogen synthase kinase 3 beta, protein phosphate 2, and itself. This protein functions as a negative regulator of the wingless-type MMTV integration site family, member 1 (WNT) signaling pathway and can induce apoptosis. The crystal structure of a portion of this protein, alone and in a complex with other proteins, has been resolved. Mutations in this gene have been associated with hepatocellular carcinoma, hepatoblastomas, ovarian endometriod adenocarcinomas, and medullablastomas. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

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