Human XLF Knockdown Cell Line-HeLa

Name: Human XLF Knockdown Cell Line-HeLa
SKU: CSC-RK0020
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CSC-RK0020

Host Cell : HeLa Validation : Real-Time RCR

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Cell Line Information

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Gene Information

Cat. No.	CSC-RK0020
Background	Double-strand breaks in DNA result from genotoxic stresses and are among the most damaging of DNA lesions. This gene encodes a DNA repair factor essential for the nonhomologous end-joining pathway, which preferentially mediates repair of double-stranded breaks. Mutations in this gene cause different kinds of severe combined immunodeficiency disorders.
Target Gene	NHEJ1
Abbr	HeLa-HuXLF Knockdown
Alias	NHEJ1, Cernunnos, FLJ12610, XLF
Host Cell	HeLa
Host Cell Species	Homo sapiens (Human)
Applications	(1) Studying gene functions (2) Studying gene interactions and signaling pathways (3) Target validation and drug discovery (4) Designing diseases models
Morphology	Epithelial
Size	>1 × 10⁶ cells / vial
Stability	Validated for at least 10 passages
Validation	Real-Time RCR
Shipping	Dry ice

Mycoplasma	Negative
Format	One frozen vial containing millions of cells
Storage	Liquid nitrogen
Safety Considerations	The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach.
Ship	Dry ice

Gene Name	NHEJ1 nonhomologous end-joining factor 1 [ Homo sapiens ]
Gene Symbol	NHEJ1
Synonyms	XLF
Gene ID	79840
Uni Prot ID	Q9H9Q4
m RNA Refseq	NM_024782.2
Protein Refseq	NP_079058.1
Chromosome Location	2q35
Function	DNA binding; protein binding;
Pathway	Non-homologous end joining, organism-specific biosystem; Non-homologous end-joining, organism-specific biosystem; Non-homologous end-joining, conserved biosystem;
MIM	611290

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