Human STAT1 Prom/Luciferase/Hyg Reporter Stable Cell Line-HeLa

Name: Human STAT1 Prom/Luciferase/Hyg Reporter Stable Cell Line-HeLa
SKU: CSC-RR0034
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CSC-RR0034

Host Cell : HeLa Size : >1x10⁶ frozen cells/vial

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Cell Line Information

Cell Culture Information

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Gene Information

Cat. No.	CSC-RR0034
Background	STAT-1 is activated upon IFNa/b, IFNg, or IL-6 binding to it"s cognate receptor. Once Stat1 is phosphorylated by JAKs it forms a homodimer, or heterodimer with STAT-2 and translocated to the nucleaus. Once in the nucleus the dimer binds to the GAS sequence (IFNg activation site) in the promoter region of target genes and induces transcription. STAT-1 can also be phosphrylated by numerous serine/threonine kinases, which increase transcriptional activity.
Target Gene	STAT1
Gene Species	Homo sapiens (Human)
Abbr	HeLa-HuSTAT1 Prom/Luciferase/Hyg
Host Cell	HeLa
Host Cell Species	Homo sapiens (Human)
Applications	1. Gene expression studies 2. Protein localization 3. Drug screening and toxicology 4. Live cell imaging
Size	>1x10⁶ frozen cells/vial
Stability	Validated for at least 10 passages
Quality Control	Negative for bacteria, yeast, fungi and mycoplasma.
Storage	Liquid nitrogen
Shipping	Dry ice

Revival	Rapidly thaw cells in a 37°C water bath. Transfer contents into a tube containing pre-warmed media. Centrifuge cells and seed into a 25 cm2 flask containing pre-warmed media.
Morphology	Epithelial

Mycoplasma	Negative
Format	One frozen vial containing millions of cells
Storage	Liquid nitrogen
Safety Considerations	The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach.
Ship	Dry ice

Gene Name	STAT1 signal transducer and activator of transcription 1, 91kDa [ Homo sapiens ]
Gene Symbol	STAT1
Synonyms	STAT1; signal transducer and activator of transcription 1, 91kDa; signal transducer and activator of transcription 1, 91kD; signal transducer and activator of transcription 1-alpha/beta; ISGF 3; STAT91; transcription factor ISGF 3 components p91/p84; transcription factor ISGF-3 components p91/p84; signal transducer and activator of transcription-1; CANDF7; ISGF-3; DKFZp686B04100;
Gene ID	6772
Uni Prot ID	P42224
m RNA Refseq	BC002704
Chromosome Location	2q32.2-q32.3
Function	RNA polymerase II core promoter sequence-specific DNA bi
Pathway	Adipogenesis, organism-specific biosystem; Antiviral mechanism by IFN-stimulated genes, organism-specific biosystem; B Cell Receptor Signaling Pathway, organism-specific biosystem; CXCR4-mediated signaling events, organism-specific biosystem; Chemokine signaling pathway, organism-specific biosystem; Chemokine signaling pathway, conserved biosystem; Cytokine Signaling in Immune system, organism-specific biosystem;
MIM	600555

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