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Human STAT1 Prom/Luciferase/Hyg Reporter Stable Cell Line-HeLa

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Cat.No.
CSC-RR0034
Background
STAT-1 is activated upon IFNa/b, IFNg, or IL-6 binding to it"s cognate receptor. Once Stat1 is phosphorylated by JAKs it forms a homodimer, or heterodimer with STAT-2 and translocated to the nucleaus. Once in the nucleus the dimer binds to the GAS sequence (IFNg activation site) in the promoter region of target genes and induces transcription. STAT-1 can also be phosphrylated by numerous serine/threonine kinases, which increase transcriptional activity.
Growth Properties
Adherent
Morphology
Epithelial
Host Cell
HeLa
Stability
Cells will undergo genotypic changes resulting in reduced responsiveness over time in normal cell culture conditions. Genetic instability is a biological phenomenon that occurs in all stably transfected cells. Therefore, it is critical to prepare an adequate number of frozen stocks at early passages.
Ship
Dry ice
Gene Information
Official Symbol
STAT1
Synonyms
STAT1; signal transducer and activator of transcription 1, 91kDa; signal transducer and activator of transcription 1, 91kD; signal transducer and activator of transcription 1-alpha/beta; ISGF 3; STAT91; transcription factor ISGF 3 components p91/p84; transcription factor ISGF-3 components p91/p84; signal transducer and activator of transcription-1; CANDF7; ISGF-3; DKFZp686B04100;
Gene ID
MIM
UniProt ID
P42224
Chromosome Location
2q32.2-q32.3
Pathway
Adipogenesis, organism-specific biosystem; Antiviral mechanism by IFN-stimulated genes, organism-specific biosystem; B Cell Receptor Signaling Pathway, organism-specific biosystem; CXCR4-mediated signaling events, organism-specific biosystem; Chemokine signaling pathway, organism-specific biosystem; Chemokine signaling pathway, conserved biosystem; Cytokine Signaling in Immune system, organism-specific biosystem;
Function
RNA polymerase II core promoter sequence-specific DNA binding; RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity; calcium ion binding; double-stranded DNA binding; enzyme binding; non-membrane spanning protein tyrosine kinase activity; protein binding; protein homodimerization activity; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; NOT sequence-specific DNA binding transcription factor activity; signal transducer activity; tumor necrosis factor receptor binding;

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