Human SLC2A8 adenoviral particles

The SLC2A8 gene, also known as GLUT8, encodes a member of the solute carrier family 2 (SLC2), which consists of facilitated glucose transporters. SLC2A8 is primarily expressed in metabolic tissues, including brain, testis, liver, and adipose tissue, where it plays a key role in glucose homeostasis. Unlike other glucose transporters, SLC2A8 has a unique intracellular localization, typically localized in endosomal or lysosomal compartments, and is regulated by insulin and other metabolic signals. Studies have shown that it is involved in glucose uptake under specific physiological conditions, such as neuronal energy supply or spermatogenesis. Dysregulation of SLC2A8 has been associated with metabolic disorders, including diabetes and obesity, making it a potential therapeutic target.

Human SLC2A8 Adenoviral Particles are genetically engineered viral vectors designed to deliver the SLC2A8 gene to target cells for functional studies or therapeutic applications. These particles are based on adenoviral technology and achieve high transduction efficiency in a variety of cell types, including primary and dividing cells. Adenoviral vectors usually contain the full-length human SLC2A8 cDNA and are regulated by a strong promoter, ensuring stable gene expression after transduction. Researchers use these particles to study the role of SLC2A8 in glucose metabolism, signal transduction, or disease mechanisms, especially in in vitro and in vivo models.