Human SLC2A7 adenoviral particles

The SLC2A7 gene encodes solute carrier family 2, member 7 (SLC2A7), a member of the facilitatory glucose transporter (GLUT) family. SLC2A7, also known as GLUT7, is primarily known for its role in the transport of monosaccharides, especially fructose, across cell membranes. Unlike other GLUT family members, SLC2A7 is highly specific for fructose and is primarily expressed in metabolically active tissues such as the liver, small intestine, and kidney. Its function is critical for nutrient absorption and energy homeostasis, making it a potential target for metabolic disorders such as diabetes and nonalcoholic fatty liver disease (NAFLD). In addition, emerging studies suggest that SLC2A7 may be involved in cancer cell metabolism, highlighting its broader physiological and pathological significance.

Human SLC2A7 adenoviral particles are genetically engineered viral vectors designed to deliver the SLC2A7 gene to target cells for functional studies or therapeutic applications. These particles are based on adenovirus, a non-enveloped DNA virus known for its high transduction efficiency, broad tropism, and stable expression of transgenes in both dividing and non-dividing cells. This adenoviral system has been modified to ensure safety by removing viral replication genes (E1/E3 deletion) and incorporating human SLC2A7 cDNA under a constitutive or tissue-specific promoter. These particles allow researchers to overexpress SLC2A7 in vitro or in vivo, facilitating the study of its role in fructose metabolism, disease pathogenesis, and potential gene therapy strategies.