Human RUNX2 adenoviral particles

RUNX2 (Runt-related transcription factor 2) gene, also known as core binding factor subunit alpha-1 (CBFA1), is a key transcription factor that regulates bone development and osteoblast differentiation. As a member of the RUNX family, RUNX2 plays a crucial role in bone formation by regulating the expression of osteogenic markers such as osteocalcin (OCN), type I collagen alpha 1 (COL1A1), and alkaline phosphatase (ALP). In addition to its key role in osteogenesis, RUNX2 is also involved in chondrocyte maturation, tooth development, and hematopoiesis. Mutations or dysregulation of RUNX2 are associated with skeletal diseases, including cleidocranial dysplasia (CCD), which is characterized by defects in bone and cartilage formation. Given its central role in bone biology, RUNX2 has become a key target for regenerative medicine, bone tissue engineering, and disease modeling research. Human RUNX2 adenoviral particles are genetically engineered viral vectors designed to efficiently deliver the RUNX2 gene to target cells. Adenoviral vectors are favored for their ability to infect both dividing and non-dividing cells, thus ensuring stable expression of the transgene. These particles typically have a replication-defective adenoviral backbone, which ensures safety by preventing viral replication while maintaining high transduction efficiency. Researchers have used these particles to study the role of RUNX2 in osteogenic differentiation, bone repair, and disease mechanisms. In addition, they are also valuable tools in preclinical studies of bone regenerative therapies.