Mouse RUNX2 ORF clone(NM_009820.5)

Name: Mouse RUNX2 ORF clone(NM_009820.5)
SKU: CDCH399382
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDCH399382

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Product Information

Gene Information

Cat. No.	CDCH399382
Product Type	ORF clone
Gene Abbr	RUNX2
Species	Mouse
Host Cell	Bacterial
Source	Bacterial
ORF Size	5865bp
Size	1ug
Format	Clear Liquid
Vector	pORF
Buffer	10mM Tris-HCI, 1mM EDTA, pH8.0
Warning	pORF-mRunx2 ORF Vector is for research use only and is not intended for therapeutic or diagnostic applications. Please contact a technical service representative for more information.
Storage	1 year when stored at -20°C or lower in a non-frost free freezer.

Target Gene

RUNX2

Background

This gene is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain. This protein is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Two regions of potential trinucleotide repeat expansions are present in the N-terminal region of the encoded protein, and these and other mutations in this gene have been associated with the bone development disorder cleidocranial dysplasia (CCD). Transcript variants that encode different protein isoforms result from the use of alternate promoters as well as alternate splicing. [provided by RefSeq, Jul 2016]

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