Human PTGFR adenoviral particles

The PTGFR gene, also known as the prostaglandin F2α receptor gene, encodes a G protein-coupled receptor (GPCR) that binds to prostaglandin F2α (PGF2α), a key lipid mediator involved in a variety of physiological processes. PTGFR plays a key role in inflammation, smooth muscle contraction, reproductive function (e.g., luteolysis and parturition), and regulation of intraocular pressure. Dysregulated PTGFR signaling has been associated with pathologies such as premature birth, glaucoma, and cardiovascular disease. Studying the function of PTGFR often requires efficient gene delivery systems, such as adenoviral vectors, to regulate its expression in vitro or in vivo.

Human PTGFR adenoviral particles are genetically engineered recombinant adenoviruses used to deliver the human PTGFR gene to target cells. These particles leverage the high transduction efficiency and broad tropism of adenoviral vectors to enable stable gene expression in both dividing and non-dividing cells. The adenoviral backbone is often modified to ensure safety, such as deleting essential replication genes (e.g., the E1/E3 region) to render the virus replication incapable. The PTGFR gene is inserted under the control of a strong promoter, ensuring high-level expression in transduced cells. These particles are ideal for applications such as functional studies, signaling pathway analysis, and drug screening, especially for difficult-to-transfect cell types such as primary smooth muscle cells or ocular tissue.