Human ELANE cDNA Clone(NM_001972.2)

Name: Human ELANE cDNA Clone(NM_001972.2)
SKU: CDFH005831
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDFH005831

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Product Information

Gene Information

Cat. No.	CDFH005831
Product Type	cDNA clone
Gene Abbr	ELANE
Species	Human
Size	10 ug
Vector	pCMV6-XL4

Target Gene

ELANE

Background

Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode structurally similar proteins. The encoded preproprotein is proteolytically processed to generate the active protease. Following activation, this protease hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix. The enzyme may play a role in degenerative and inflammatory diseases through proteolysis of collagen-IV and elastin. This protein also degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN). This gene is present in a gene cluster on chromosome 19. [provided by RefSeq, Jan 2016]

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