Human ELANE ORF Clone(NM_001972.2)

Name: Human ELANE ORF Clone(NM_001972.2)
SKU: CDCR282013
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDCR282013

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Product Information

Gene Information

Cat. No.	CDCR282013
Product Type	ORF Clone
Gene Abbr	ELANE
Species	Human
Tag	C-terminal Myc-DDK
ORF Size	804 bp
Size	10 ug
Vector	pCMV6-Entry

Target Gene

ELANE

Background

Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode structurally similar proteins. The encoded preproprotein is proteolytically processed to generate the active protease. Following activation, this protease hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix. The enzyme may play a role in degenerative and inflammatory diseases through proteolysis of collagen-IV and elastin. This protein also degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN). This gene is present in a gene cluster on chromosome 19. [provided by RefSeq, Jan 2016]

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