Human DNMT3A adenoviral particles

Name: Human DNMT3A adenoviral particles
SKU: AD05013Z
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : AD05013Z

Storage : -80℃ Shipping : Frozen on dry ice

Titer: Size:

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Virus Particles Information

Quality Control

Gene Information

Cat. No.	AD05013Z
Description	Adenovirus with ORF of DNA (cytosine-5-)-methyltransferase 3 alpha (DNMT3A), transcript variant 1.
Gene	DNMT3A
Species	Human
Titer	Varies lot by lot, for example, ≥1x10^10 IFU/mL, ≥1x10^11 IFU/mL, ≥1x10^11 VP/mL etc.
Size	Varies lot by lot, for example, 100 ul, 500 ul, 1 mL etc.
Storage	Store at -80℃. Avoid multiple freeze/thaw cycles.
Shipping	Frozen on dry ice

Summary	Creative Biogene ensures high-quality adenovirus particles by optimizing and standardizing production protocols and performing stringent quality control (QC). The specific QC experiments performed vary between adenovirus particle lots.
Endotoxin	Endotoxins, primarily derived from Gram-negative bacteria, can trigger adverse immune responses. Endotoxin contamination is a significant concern in adenovirus production, especially for applications in animal studies and gene therapy. Creative Biogene utilizes rigorous endotoxin detection methods to monitor the endotoxin level in our produced adenovirus particles to ensure regulatory compliance.
Sterility	Creative Biogene ensures that adenovirus products are free of any bacterial, fungal and other microbial contamination.
Ad5 E1 Detection	All Creative Biogene adenoviruses are PCR tested to ensure that there are no detectable E1 sequences in the particles, which could be from revertants or external E1 contamination.
RCA Assays	Adenovirus products originating at Creative Biogene are guaranteed to have undetectable replication-competent adenovirus (RCA). This quality control measure is important because there is always the possibility of wild-type contamination due to revertants or environmental sources.
PFU Titering	All purified adenovirus preparations are tested for infectious titer. Creative Biogene's PFU test takes a few days longer but counts true plaques in HEK cells rather than estimating PFU titers via IHC staining or TCI50 of infected cells.

Gene Name	DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha [ Homo sapiens ]
Gene Symbol	DNMT3A
Synonyms	DNMT3A2; M.HsaIIIA
Gene Description	DNA (cytosine-5-)-methyltransferase 3 alpha
GeneID	1788
Uni ProtID	Q9Y6K1
mRNA Refseq	NM_175630.1
Protein Refseq	NP_783329.1
Chromosome Location	2p23
Function	DNA (cytosine-5-)-methyltransferase activity; DNA binding; chromatin binding; metal ion binding; protein binding;
Pathway	Cysteine and methionine metabolism, organism-specific biosystem; Cysteine and methionine metabolism, conserved biosystem; Methionine degradation, organism-specific biosystem; Methionine degradation, conserved biosystem; One Carbon Metabolism, organism-specific biosystem; Validated targets of C-MYC transcriptional repression, organism-specific biosystem;
MIM	602769

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