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Human BLM Knockdown Cell Line-HeLa

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Cat.No.
CSC-RK0025
Background
The Bloom syndrome gene product is related to the RecQ subset of DExH box-containing DNA helicases and has both DNA-stimulated ATPase and ATP-dependent DNA helicase activities. Mutations causing Bloom syndrome delete or alter helicase motifs and may disable the 3"-5" helicase activity. The normal protein may act to suppress inappropriate recombination.
Growth Properties
Adherent
Morphology
Epithelial
Host Cell
HeLa
Ship
Dry ice
Gene Information
Official Symbol
BLM
Synonyms
BLM; Bloom syndrome, RecQ helicase-like; Bloom syndrome; Bloom syndrome protein; BS; RECQ2; RECQL3; recQ protein-like 3; DNA helicase, RecQ-like type 2; RECQL2; MGC126616; MGC131618; MGC131620;
Gene ID
MIM
UniProt ID
P54132
Chromosome Location
15q26.1
Pathway
BRCA1-associated genome surveillance complex (BASC), organism-specific biosystem; Blooms syndrome complex, organism-specific biosystem; Fanconi anemia pathway, organism-specific biosystem; Fanconi anemia pathway, conserved biosystem; Homologous recombination, organism-specific biosystem; Homologous recombination, conserved biosystem; Meiosis, organism-specific biosystem;
Function
ATP binding; ATP-dependent 3-5 DNA helicase activity; ATP-dependent DNA helicase activity; ATP-dependent helicase activity; ATPase activity; DNA binding; DNA strand annealing activity; G-quadruplex DNA binding; bubble DNA binding; four-way junction helicase activity; helicase activity; hydrolase activity; hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides; nucleotide binding; p53 binding; protein binding; single-stranded DNA binding;

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