Human BLM Knockdown Cell Line-HeLa

Name: Human BLM Knockdown Cell Line-HeLa
SKU: CSC-RK0025
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CSC-RK0025

Host Cell : HeLa Validation : Real-Time RCR

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Cell Line Information

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Gene Information

Cat. No.	CSC-RK0025
Background	The Bloom syndrome gene product is related to the RecQ subset of DExH box-containing DNA helicases and has both DNA-stimulated ATPase and ATP-dependent DNA helicase activities. Mutations causing Bloom syndrome delete or alter helicase motifs and may disable the 3"-5" helicase activity. The normal protein may act to suppress inappropriate recombination.
Target Gene	BLM
Abbr	HeLa-HuBLM Knockdown
Alias	BLM, BS, RECQ2, RECQL3, RECQL2, MGC126616, MGC131618, MGC131620
Host Cell	HeLa
Host Cell Species	Homo sapiens (Human)
Applications	(1) Studying gene functions (2) Studying gene interactions and signaling pathways (3) Target validation and drug discovery (4) Designing diseases models
Morphology	Epithelial
Size	>1 × 10⁶ cells / vial
Stability	Validated for at least 10 passages
Validation	Real-Time RCR
Shipping	Dry ice

Mycoplasma	Negative
Format	One frozen vial containing millions of cells
Storage	Liquid nitrogen
Safety Considerations	The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach.
Ship	Dry ice

Gene Name	BLM Bloom syndrome, RecQ helicase-like [ Homo sapiens ]
Gene Symbol	BLM
Synonyms	BS; RECQ2; RECQL2; RECQL3
Gene ID	641
Uni Prot ID	P54132
m RNA Refseq	NM_000057.2
Protein Refseq	NP_000048.1
Chromosome Location	15q26.1
Function	ATP binding; ATP-dependent 3-5 DNA helicase activity; ATP-dependent DNA helicase activity; ATP-dependent DNA helicase activity; ATP-dependent helicase activity; ATPase activity; G-quadruplex DNA binding; bubble DNA binding; four-way junction helicase activity; helicase activity; p53 binding; protein binding; single-stranded DNA binding;
Pathway	BRCA1-associated genome surveillance complex (BASC), organism-specific biosystem; Blooms syndrome complex, organism-specific biosystem; Fanconi anemia pathway, organism-specific biosystem; Fanconi anemia pathway, conserved biosystem; Homologous recombination, organism-specific biosystem; Homologous recombination, conserved biosystem; Integrated Breast Cancer Pathway, organism-specific biosystem;
MIM	604610

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