Human ADAM17 Knockdown Cell Line-HeLa

Name: Human ADAM17 Knockdown Cell Line-HeLa
SKU: CSC-RK0254
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CSC-RK0254

Host Cell : HeLa Validation : Real-Time RCR

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Cell Line Information

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Gene Information

Cat. No.	CSC-RK0254
Background	This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene functions as a tumor necrosis factor-alpha converting enzyme; binds mitotic arrest deficient 2 protein; and also plays a prominent role in the activation of the Notch signaling pathway.
Target Gene	ADAM17
Abbr	HeLa-HuADAM17 Knockdown
Alias	ADAM17, CD156B, cSVP, CSVP, TACE, NISBD, ADAM18
Host Cell	HeLa
Host Cell Species	Homo sapiens (Human)
Applications	(1) Studying gene functions (2) Studying gene interactions and signaling pathways (3) Target validation and drug discovery (4) Designing diseases models
Morphology	Epithelial
Size	>1 × 10⁶ cells / vial
Stability	Validated for at least 10 passages
Validation	Real-Time RCR
Shipping	Dry ice

Mycoplasma	Negative
Format	One frozen vial containing millions of cells
Storage	Liquid nitrogen
Safety Considerations	The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach.
Ship	Dry ice

Gene Name	ADAM17 ADAM metallopeptidase domain 17 [ Homo sapiens ]
Gene Symbol	ADAM17
Synonyms	CSVP; TACE; NISBD; ADAM18; CD156B
Gene Description	ADAM metallopeptidase domain 17 (tumor necrosis factor, alpha, converting enzyme)
GeneID	6868
Uni ProtID	B2RNB2
mRNA Refseq	NM_003183.4
Protein Refseq	NP_003174.3
Chromosome Location	2p25
Function	PDZ domain binding; SH3 domain binding; integrin binding; interleukin-6 receptor binding; metalloendopeptidase activity; metalloendopeptidase activity; metalloendopeptidase activity; metallopeptidase activity; metallopeptidase activity; metallopeptidase activity; protein binding; zinc ion binding;
Pathway	Activated NOTCH1 Transmits Signal to the Nucleus, organism-specific biosystem; Alzheimers disease, organism-specific biosystem; Alzheimers disease, conserved biosystem; Alzheimers Disease, organism-specific biosystem; Cytokine Signaling in Immune system, organism-specific biosystem; Delta-Notch Signaling Pathway, organism-specific biosystem; Disease, organism-specific biosystem;
MIM	603639

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