shRNA set against Mouse RNF139 (NM_175226.4)

Name: shRNA set against Mouse RNF139 (NM_175226.4)
SKU: SHH396740
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : SHH396740

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Product Information

Gene Information

Cat. No.	SHH396740
Description	The SureSilencing trade; shRNA Plasmids are designed to specifically knock down the expression of individual genes by RNA interference under either transient (with GFP) or stable transfection (for hygromycin, neomycin or puromycin-resistance) conditions after performance of the appropriate enrichment or selection procedures, respectively. Each vector contains the shRNA under control of the U1 promoter and either the GFP gene, for the enrichment of transiently transfected cells, or the neomycin or puromycin resistance genes, for the selection of stably transfected cells.
Gene Abbr	RNF139
Species	Mouse
Report Gene	GFP
Storage	The SureSilencing shRNA Plasmids are shipped on dry ice or cold packs. Store all tubes at -20°C.

Target Gene

RNF139

Background

The protein encoded by this gene is a multi-membrane spanning protein containing a RING-H2 finger. This protein is located in the endoplasmic reticulum, and has been shown to possess ubiquitin ligase activity. This gene was found to be interrupted by a t(3:8) translocation in a family with hereditary renal and non-medulary thyroid cancer. Studies of the Drosophila counterpart suggested that this protein may interact with tumor suppressor protein VHL, as well as with COPS5/JAB1, a protein responsible for the degradation of tumor suppressor CDKN1B/P27KIP. [provided by RefSeq, Jul 2008]

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