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Rat Rnf139 cDNA Clone(NM_001127545.1)

For research use only. Not intended for any clinical use.

Cat. No. :   CDFR009571

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Gene Information

Cat. No. CDFR009571
Description NativeORF clone of Rattus norvegicus ring finger protein 139 (Rnf139) as transfection-ready DNA NM_001127545.1
Product Type cDAN Clone
Gene Abbr Rnf139
Species Rat
Vector pCMV6Entry
Target Gene RNF139
Background The protein encoded by this gene is a multi-membrane spanning protein containing a RING-H2 finger. This protein is located in the endoplasmic reticulum, and has been shown to possess ubiquitin ligase activity. This gene was found to be interrupted by a t(3:8) translocation in a family with hereditary renal and non-medulary thyroid cancer. Studies of the Drosophila counterpart suggested that this protein may interact with tumor suppressor protein VHL, as well as with COPS5/JAB1, a protein responsible for the degradation of tumor suppressor CDKN1B/P27KIP. [provided by RefSeq, Jul 2008]
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