shRNA set against Human SIRT1 (NM_012238.4)

Name: shRNA set against Human SIRT1 (NM_012238.4)
SKU: SHH407728
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : SHH407728

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Product Information

Gene Information

Cat. No.	SHH407728
Description	The SureSilencing trade; shRNA Plasmids are designed to specifically knock down the expression of individual genes by RNA interference under either transient (with GFP) or stable transfection (for hygromycin, neomycin or puromycin-resistance) conditions after performance of the appropriate enrichment or selection procedures, respectively. Each vector contains the shRNA under control of the U1 promoter and either the GFP gene, for the enrichment of transiently transfected cells, or the neomycin or puromycin resistance genes, for the selection of stably transfected cells.
Gene Abbr	SIRT1
Gene Name	SIRT1 sirtuin 1 [ Homo sapiens ]
Species	Human
Report Gene	GFP
Storage	The SureSilencing shRNA Plasmids are shipped on dry ice or cold packs. Store all tubes at -20°C.

Gene Name	SIRT1 sirtuin 1 [ Homo sapiens ]
Gene Symbol	SIRT1
Synonyms	SIR2L1
Gene Description	sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae)
GeneID	23411
Uni ProtID	A8K128
mRNA Refseq	NM_001142498.1
Protein Refseq	NP_001135970.1
Chromosome Location	10q21.3
Function	HLH domain binding; NOT NAD+ ADP-ribosyltransferase activity; NAD+ binding; NAD-dependent histone deacetylase activity; NAD-dependent histone deacetylase activity (H3-K9 specific); NAD-dependent protein deacetylase activity; NAD-dependent protein deacetylase activity; bHLH transcription factor binding; deacetylase activity; histone binding; histone deacetylase activity; identical protein binding; metal ion binding; mitogen-activated protein kinase binding; p53 binding; protein C-terminus binding; protein binding; protein deacetylase activity; transcription corepressor activity; transcription corepressor activity;
Pathway	Amphetamine addiction, organism-specific biosystem; Amphetamine addiction, conserved biosystem; E2F transcription factor network, organism-specific biosystem; Energy Metabolism, organism-specific biosystem; FoxO family signaling, organism-specific biosystem; HIF-2-alpha transcription factor network, organism-specific biosystem; Integrated Breast Cancer Pathway, organism-specific biosystem;
MIM	604479

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