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SARS-CoV-2 Truncated S(D614G)-Pseudotyped Lentivirus Packaging Kit

For research use only. Not intended for any clinical use.
Cat.No.
CPK004
Description
This kit contains packaging plasmid mix required for producing HIV-based, replication-deficient, SARS-CoV-2 truncated S(D614G)-pseudotyped lentivirus.
Applications
COVID, SARS-CoV-2 research

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Customer Q&As
Can lentiviral vectors achieve stable gene expression?

A: Lentiviruses can integrate their viral genome into the host cell's DNA, resulting in stable and long-term expression of the delivered genes.

Are lentiviruses less immunogenic?

A: Yes. Lentiviruses have relatively low immunogenicity compared to other viral vectors. This reduces the risk of triggering an immune response in the treated individual, which could potentially affect safety and efficacy.

What are pseudotyped lentiviruses?

A: Pseudotyped lentiviral vectors consist of vector particles bearing glycoproteins (GPs) from other enveloped viruses. These particles have the tropism of GP-derived viruses.

What is the purpose of pseudotyping?

A: Pseudotyping allows researchers to study the characteristics and behavior of a specific virus by using a different virus with known properties. By swapping the coat proteins, the resulting pseudotyped virus can borrow the infectivity and entry mechanisms of the original virus, while containing the genetic material of the virus being studied.

What is SARS-CoV-2 Truncated S(D614G)?

A: SARS-CoV-2 Truncated S (D614G) refers to a specific variant of the virus that has a mutation at position 614 of the Spike protein. In this variant, the amino acid aspartate (D) is replaced by glycine (G) at position 614. This mutation is commonly referred to as "D614G".

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Customer Reviews
Worked very well

The SARS-CoV-2 Truncated S(D614G)-Pseudotyped Lentivirus Packaging Kit provides us with a reproducible and streamlined lentivirus production process.

United States

07/19/2022

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