Recombinant Mouse GHR (C-Fc)

Name: Recombinant Mouse GHR (C-Fc)
SKU: RP00289

Cat.No. : RP00289 Tag: C-Fc

Expressed Region: Met1-Gln273 Expression System: Human Cell

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Product Details

Target Information

Cat. No.	RP00289
Description	The Recombinant Mouse GHR (C-Fc) is produced in our Human Cell expression system. The amino acid region expressed is Met1-Gln273 with a Fc tag at the C terminus.
Species	Mouse
Tag	C-Fc
Mol. Weight	58.3 KDa
Expressed Region	Met1-Gln273
Expression System	Human Cell
Format	Powder
Formulation	Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Conjugate	Unconjugated
Endotoxin Level	< 1 EU/µg of protein by LAL method
Purity	>95% as determined by SDS-PAGE. >90% as determined by SEC-MALS.
Shipping	The product is shipped with ice packs. Upon receipt, store it immediately at the temperature recommended below.
Storage	Upon receipt, this product is stable for up to 6 months at temperatures below -70°C. Once reconstituted, the product is stable for up to 1 week at 4°C and up to 3 months at -20°C. Please avoid repeated freeze-thaw cycles.
Reconstitution	Always centrifuge tubes before opening. It is recommended to reconstitute the solution to a concentration above 100 μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Target Gene	Ghr
Background	This gene encodes a member of the type I cytokine receptor family, which is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. In humans and rabbits, but not rodents, growth hormone binding protein (GHBP) is generated by proteolytic cleavage of the extracellular ligand-binding domain from the mature growth hormone receptor protein. Multiple alternatively spliced transcript variants have been found for this gene.
Synonyms	growth hormone binding protein; growth hormone receptor; serum binding protein; Somatotropin receptor;GHR; GH receptor; GHBP

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