Recombinant Human SELPLG (C-Fc)

Name: Recombinant Human SELPLG (C-Fc)
SKU: RP00623
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : RP00623 Tag : C-Fc

Expressed Region : Gln42-Gly295 Expression System : Human Cell

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Product Information

Gene Information

Cat. No.	RP00623
Description	Recombinant Human SELPLG (C-Fc) is produced in our Human Cell expression system. The amino acid region expressed is Gln42-Gly295 with a Fc tag at the C terminus.
Species	Human
Tag	C-Fc
Mol Weight	52.9 KDa
Conjugate	Unconjugated
Format	Powder
Expressed Region	Gln42-Gly295
Expression System	Human Cell
Formulation	Lyophilized from a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, pH 8.0.
Purity	>95% as determined by SDS-PAGE. >90% as determined by SEC-MALS.
Endotoxin Level	< 1 EU/µg of protein by LAL method
Storage	Upon receipt, this product is stable for up to 6 months at temperatures below -70°C. Once reconstituted, the product is stable for up to 1 week at 4°C and up to 3 months at -20°C. Please avoid repeated freeze-thaw cycles.
Shipping	The product is shipped with ice packs. Upon receipt, store it immediately at the temperature recommended below.
Reconstitution	Always centrifuge tubes before opening. It is recommended to reconstitute the solution to a concentration above 100 μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Target Gene	SELPLG
Synonyms	P-selectin glycoprotein ligand 1; PSGL-1; Selectin P ligand; CD162; SELPLG

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This gene encodes a glycoprotein that functions as a high affinity counter-receptor for the cell adhesion molecules P-, E- and L- selectin expressed on myeloid cells and stimulated T lymphocytes. As such, this protein plays a critical role in leukocyte trafficking during inflammation by tethering of leukocytes to activated platelets or endothelia expressing selectins. This protein requires two post-translational modifications, tyrosine sulfation and the addition of the sialyl Lewis x tetrasaccharide (sLex) to its O-linked glycans, for its high-affinity binding activity. Aberrant expression of this gene and polymorphisms in this gene are associated with defects in the innate and adaptive immune response. Alternate splicing results in multiple transcript variants.

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