Recombinant Human MGMT (N-6His)

Name: Recombinant Human MGMT (N-6His)
SKU: RP00230
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : RP00230 Tag : N-6His

Expressed Region : Met1-Asn207 Expression System : E.coli

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Product Information

Gene Information

Cat. No.	RP00230
Description	The Recombinant Human MGMT (N-6His) is produced in our E.coli expression system. The amino acid region expressed is Met1-Asn207 with a 6His tag at the N terminus.
Species	Human
Tag	N-6His
Mol Weight	23.8 KDa
Conjugate	Unconjugated
Format	Liquid
Expressed Region	Met1-Asn207
Expression System	E.coli
Formulation	Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl,1mM DTT,1mM EDTA,500mM NaCl,0.1%Trition X-100,pH 8.0.
Purity	>95% as determined by SDS-PAGE. >90% as determined by SEC-MALS.
Endotoxin Level	< 1 EU/µg of protein by LAL method
Storage	Upon receipt, this product is stable for up to 6 months at temperatures below -70°C. Once reconstituted, the product is stable for up to 1 week at 4°C and up to 3 months at -20°C. Please avoid repeated freeze-thaw cycles.
Shipping	The product is shipped with ice packs. Upon receipt, store it immediately at the temperature recommended below.

Target Gene	MGMT
Background	Alkylating agents are potent carcinogens that can result in cell death, mutation and cancer. The protein encoded by this gene is a DNA repair protein that is involved in cellular defense against mutagenesis and toxicity from alkylating agents. The protein catalyzes transfer of methyl groups from O(6)-alkylguanine and other methylated moieties of the DNA to its own molecule, which repairs the toxic lesions. Methylation of the genes promoter has been associated with several cancer types, including colorectal cancer, lung cancer, lymphoma and glioblastoma.
Synonyms	Methylated-DNA--protein-cysteine methyltransferase; 6-O-methylguanine-DNAmethyltransferase;O-6-methylguanine-DNA-alkyltransferase; MGMT

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