Human MGMT Stable Cell Line - GL261

MGMT, or O-6-methylguanine-DNA methyltransferase, is an important enzyme that repairs DNA. Specifically, it repairs the DNA molecule at the O6-methylguanine site by transferring the methyl group at the lesion to the cysteine residue in its active site. This enzyme plays a vital role in the stability and integrity of genetic material within cells and is critical for preventing mutations that can lead to diseases such as cancer. Its primary function involves DNA repair, specifically the repair of alkylated DNA. Studies have shown that loss of MGMT function sensitizes cells to alkylating agents, forming the basis for one of the chemotherapy strategies. Mutations in this gene are associated with defects in DNA repair and increased susceptibility to certain types of cancer. Therefore, MGMT is a potential target for cancer therapy.

Human MGMT Stable Cell Line - GL261 is a carefully engineered cell line that stably overexpresses human MGMT. GL261 refers to a specific glioma cell line known for its consistent and reproducible behavior in experimental settings. The human MGMT stable cell line - GL261 provides researchers with a powerful and reliable platform to study MGMT function, DNA repair mechanisms and related disease processes.