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Cat.No. : CSC-RR01247 Host Cell: THP1
| Cat. No. | CSC-RR01247 |
| Description | THP1-NFAT-Luc cell line is engineered to express luciferase reporter gene under the control of NFAT response element. It is a useful cell model for studying NFAT signaling pathway in THP1 cells. |
| Gene | NFAT-Luc |
| Host Cell | THP1 |
| Host Cell Species | Homo sapiens (Human) |
| Stability | This cell line is stable at least 10 passages. |
| Product Type | Signaling Pathway Reporter Cell Lines |
| Applications | Employed to detect and quantify NFAT (nuclear factor of activated T cells) signaling pathway activation, e.g., in response to immune stimuli, drugs, or environmental factors, using luciferase activity as a readout. |
| Size Form | One vial of frozen cells, typically >1x10^6cells/vial |
| Shipping | Dry ice |
| Storage | Liquid nitrogen |
| Revival | Rapidly thaw cells in a 37°C water bath. Transfer contents into a tube containing pre-warmed media. Centrifuge cells and seed into a 25 cm2 flask containing pre-warmed media. |
| Growth Properties | Suspension cell line |
| Mycoplasma | Negative |
| Format | One frozen vial containing millions of cells |
| Storage | Liquid nitrogen |
| Safety Considerations |
The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach. |
| Ship | Dry ice |
If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.
We used this NFAT-Luc THP1 line to screen for immunomodulators, and the signal-to-noise ratio is excellent. Upon stimulation with PMA/Ionomycin, the luciferase induction was strong and dose-dependent. It is a very convenient "ready-to-use" system that saved us months of assay development time.
French
11/26/2022
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