mScarlet/LUC Reporter Cell Line - A2780

A2780 is a human ovarian carcinoma cell line originally established from an untreated ovarian tumor and is one of the most extensively utilized models for ovarian cancer research. The cell line exhibits epithelial characteristics and has been widely employed in studies of tumor biology, chemotherapeutic response, and mechanisms of drug resistance. A2780 is particularly valued for investigations involving platinum-based chemotherapy, as it serves as a foundational model for comparing chemosensitive and chemoresistant ovarian cancer phenotypes. The mScarlet/LUC Reporter Cell Line - A2780 is generated through stable genetic modification to co-express the red fluorescent protein mScarlet and firefly luciferase (LUC) reporter genes. This dual-reporter system enables highly sensitive fluorescence visualization and quantitative bioluminescence imaging while maintaining the growth characteristics, morphology, and tumorigenic properties of the parental A2780 cell line.

The A2780-mScarlet/LUC reporter cell line is widely applied in ovarian cancer research for monitoring tumor growth, metastatic dissemination, and therapeutic efficacy in both in vitro and in vivo models. Luciferase expression enables non-invasive, real-time assessment of tumor burden through bioluminescence imaging, allowing longitudinal evaluation of disease progression and treatment response in xenograft studies. The bright and photostable mScarlet fluorescence facilitates high-resolution visualization of cellular morphology, proliferation, migration, invasion, and tissue localization. This model is particularly useful for screening anti-cancer compounds, evaluating platinum-based chemotherapy regimens, and investigating molecular mechanisms underlying chemoresistance and tumor recurrence. In addition, the dual-reporter platform supports studies of tumor microenvironment interactions, epithelial–mesenchymal transition, cancer stem cell-associated properties, and signaling pathways involved in ovarian cancer progression. Owing to its stable reporter expression and robust imaging capabilities, the A2780-mScarlet/LUC cell line provides a reliable and reproducible tool for preclinical drug discovery and translational research in ovarian carcinoma.