Human TRPM1 Nanodisc

Name: Human TRPM1 Nanodisc
SKU: OE-PNDC000327
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : OE-PNDC000327

Tag : C-Flag tag and Strep Tag Expression System : Mammalian expression system

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Product Information

Gene Information

Cat. No.	OE-PNDC000327
Description	Human TRPM1 nanodisc contains full length human TRPM1 protein that is produced from HEK293 cells. Our nanodisc platform employs the mammalian expression system, which ensures that the Human TRPM1 protein closely resembles its native counterpart in terms of structure, function, and post-translational modifications, while maintaining exceptional solubility and stability. This nanodisc is an optimal tool for investigating the Human TRPM1 membrane protein.
Gene Abbr	TRPM1
Gene Name	TRPM1
Species	Human
Gene Species	Human
Tag	C-Flag tag and Strep Tag
Features	1) Full-length membrane protein 2) Utilizing a mammalian expression system to ensure that the protein closely resembles its native counterpart in terms of structure, function, and post-translational modifications 3) Maintaining the native spatial conformation and activity of the membrane protein 4) Possessing high solubility and stability 5) High purity determined by HPLC 6) No detergents need to be added in subsequent experiments, and it can be directly applied to cytological analysis
Applications	1) Studying protein structure and function: Understanding the structure and activity of membrane proteins in a native-like environment. 2) Studying protein-protein and protein-ligand interactions: Analyzing how membrane proteins interact with other molecules, such as antibodies or other proteins. 3) Drug discovery: Identifying and characterizing potential drug candidates that target membrane proteins. 4) Developing antibodies: Screening and characterizing antibodies that bind to membrane proteins.
Format	Lyophilized protein
Expression System	Mammalian expression system
Note	For Research Use Only.
Storage	Store at -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within one month, aliquot and store at -80°C. Repeated freeze-thaw cycles should be avoided.
Shipping	Lyophilized proteins are shipped under ambient temperature conditions.

Target Gene

TRPM1

Background

This gene encodes a member of the transient receptor potential melastatin subfamily of transient receptor potential ion channels. The encoded protein is a calcium permeable cation channel that is expressed in melanocytes and may play a role in melanin synthesis. Specific mutations in this gene are the cause autosomal recessive complete congenital stationary night blindness-1C. The expression of this protein is inversely correlated with melanoma aggressiveness and as such it is used as a prognostic marker for melanoma metastasis. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2011]

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