Human GRM5 Nanodisc

Name: Human GRM5 Nanodisc
SKU: OE-PNDC000632
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : OE-PNDC000632

Tag : C-Flag tag and Strep Tag Expression System : Mammalian expression system

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Product Information

Gene Information

Cat. No.	OE-PNDC000632
Description	Human GRM5 nanodisc contains full length human GRM5 protein that is produced from HEK293 cells. Our nanodisc platform employs the mammalian expression system, which ensures that the Human GRM5 protein closely resembles its native counterpart in terms of structure, function, and post-translational modifications, while maintaining exceptional solubility and stability. This nanodisc is an optimal tool for investigating the Human GRM5 membrane protein.
Gene Abbr	GRM5
Gene Name	GRM5
Species	Human
Gene Species	Human
Tag	C-Flag tag and Strep Tag
Features	1) Full-length membrane protein 2) Utilizing a mammalian expression system to ensure that the protein closely resembles its native counterpart in terms of structure, function, and post-translational modifications 3) Maintaining the native spatial conformation and activity of the membrane protein 4) Possessing high solubility and stability 5) High purity determined by HPLC 6) No detergents need to be added in subsequent experiments, and it can be directly applied to cytological analysis
Applications	1) Studying protein structure and function: Understanding the structure and activity of membrane proteins in a native-like environment. 2) Studying protein-protein and protein-ligand interactions: Analyzing how membrane proteins interact with other molecules, such as antibodies or other proteins. 3) Drug discovery: Identifying and characterizing potential drug candidates that target membrane proteins. 4) Developing antibodies: Screening and characterizing antibodies that bind to membrane proteins.
Format	Lyophilized protein
Expression System	Mammalian expression system
Note	For Research Use Only.
Storage	Store at -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within one month, aliquot and store at -80°C. Repeated freeze-thaw cycles should be avoided.
Shipping	Lyophilized proteins are shipped under ambient temperature conditions.

Target Gene

Grm5

Background

Enables protein tyrosine kinase activator activity. Involved in several processes, including cellular response to amyloid-beta; learning or memory; and positive regulation of calcium-mediated signaling. Acts upstream of or within learning; locomotory behavior; and regulation of long-term neuronal synaptic plasticity. Located in cytoplasm; neuron projection; and plasma membrane. Is active in Schaffer collateral - CA1 synapse and dendrite. Is expressed in central nervous system and retina. Used to study schizophrenia. Orthologous to human GRM5 (glutamate metabotropic receptor 5). [provided by Alliance of Genome Resources, Feb 2025]

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