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Cat.No. : CSC-RR01250 Host Cell: THP1
| Cat. No. | CSC-RR01250 |
| Description | THP1-CRE-Luc cell line is engineered to express luciferase reporter gene under the control of CRE (cAMP Response Element). It is a useful cell model for studying the CREB/CRE signaling pathway in THP1 cells. |
| Gene | CRE-Luc |
| Host Cell | THP1 |
| Host Cell Species | Homo sapiens (Human) |
| Stability | This cell line is stable at least 10 passages. |
| Product Type | Signaling Pathway Reporter Cell Lines |
| Applications | Applied to detect cAMP response element (CRE)-driven signaling (e.g., PKA pathway activation); suitable for studying GPCR-mediated signaling, hormone effects, or compounds regulating cAMP-dependent processes. |
| Size Form | One vial of frozen cells, typically >1x10^6cells/vial |
| Shipping | Dry ice |
| Storage | Liquid nitrogen |
| Revival | Rapidly thaw cells in a 37°C water bath. Transfer contents into a tube containing pre-warmed media. Centrifuge cells and seed into a 25 cm2 flask containing pre-warmed media. |
| Growth Properties | Suspension cell line |
| Mycoplasma | Negative |
| Format | One frozen vial containing millions of cells |
| Storage | Liquid nitrogen |
| Safety Considerations |
The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach. |
| Ship | Dry ice |
If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.
We purchased this line to investigate GPCR signaling in a monocytic background. The response to Forskolin was immediate and high-fold, proving the functionality of the CRE-Luc construct. It simplifies the monitoring of cAMP levels significantly compared to traditional ELISA methods. Very satisfied with the performance.
Germany
06/05/2025
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