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Cat. No. : VLP-0010
| Cat. No. | VLP-0010 |
| Description | Non-infectious Norovirus GI.1 VP1 Virus-Like Particles consist of VP1 structural protein without genome. The VLPs are produced in baculovirus-infected insect cells. |
| Background | Noroviruses (NoV) are a genetically diverse group of single-stranded positive-sense RNA, non-enveloped viruses belonging to the family Caliciviridae. Noroviruses can genetically be classified into at least seven different genogroups (GI, GII, GIII, GIV, GV, GVI, and GVII), which can be further divided into different genetic clusters or genotypes. Noroviruses contain a linear, non-segmented, positive-sense RNA genome of approximately 7.5 kilobases, encoding a large polyprotein which is cleaved into six smaller non-structural proteins (NS1/2 to NS7) by the viral 3C-like protease (NS6), a major structural protein (VP1) of about 58~60 kDa and a minor capsid protein (VP2). |
| Storage | -80˚C |
| Shipping | Dry ice |
A: Norovirus-Like Particle (GI.1) lacks the ability to replicate or cause infections like the actual GI.1 strain of norovirus. It mainly serves as a tool for scientists to investigate the structure, behavior, and immune response to noroviruses, assisting in developing preventive measures and treatments.
A: The Norovirus-Like Particle (GI.1) product can be utilized in various research applications related to norovirus studies. It can serve as an antigen in diagnostic assays, allowing the detection and identification of norovirus infections. Researchers can also use these particles to develop and evaluate vaccine candidates for norovirus. The ability to work with synthetic particles provides a safer and more controlled environment for studying the virus, helping advance our understanding of norovirus biology and supporting the development of preventive measures.
A: While specific storage and handling instructions may vary, it is generally recommended to store the Norovirus-Like Particle (GI.1) product at a temperature of -70°C or below. This ensures the stability and integrity of the particles. It is advised to aliquot the product into smaller volumes upon receipt to avoid repeated freeze-thaw cycles. Additionally, appropriate biosafety practices should be followed when working with this product, including the use of personal protective equipment and adherence to local regulations and guidelines for working with infectious agents, even though Norovirus-Like Particles are non-infectious themselves.
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